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There is no proof that cannabis can cause a psychosis with people who don't have a history of psychotic behavior or a tendency for psychosis. It is a fact that only a small percentage of the estimated 300,000 people who smoke cannabis in Holland become psychotic. As far as we know it only concerns people who are consciously or unconsciously sensitive for psychosis. However, it is possible that cannabis can turn out badly with "healthy" people as well and cause anxiety or depression. Fortunately, these symptoms will not last and quickly disappear. There is no proof whatsoever that long-term and daily use of cannabis can cause a psychosis among "healthy" people, but the risk cannot be totally ignored. There are examples of people in India who - after years of daily use - started to show symptoms similar to psychosis, like hallucinations, delusions and total introversion. However, these are just descriptions of cases and are not scientifically proven.
So cannabis is almost positively harmful to people who tend to psychosis. Therefore, in 1993 research was done at the Academic Medical Center in Amsterdam (AMC) among 93 psychotic patients. It showed that 61% of the patients who used cannabis during 15 months, more than once a day, fell back into a psychosis. Almost every user suffering from psychosis turned out to use cannabis at least a year before their first psychosis. According to the researcher it meant that the use of cannabis by vulnerable people could result in developing a psychosis. (Source: Don Linszen et al., Archives of General Psychiatry 1994).
Further research to the use of cannabis by people with a tendency to psychosis shows that:
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