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Researchers have found that THC changes the way in which sensory information gets into and is acted on by the hippocampus. This is a component of the brain's limbic system that is crucial for learning, memory, and the integration of sensory experiences with emotions and motivations. Investigations have shown that neurons in the information processing system of the hippocampus and the activity of the nerve fibers are suppressed by THC. In addition, researchers have discovered that learned behaviors, which depend on the hippocampus, also deteriorate.
Recent research findings also indicate that long-term use of marijuana produces changes in the brain similar to those seen after long-term use of other major drugs of abuse.
Someone who smokes marijuana regularly may have many of the same respiratory problems that tobacco smokers have. These individuals may have daily cough and phlegm, symptoms of chronic bronchitis, and more frequent chest colds. Continuing to smoke marijuana can lead to abnormal functioning of lung tissue injured or destroyed by marijuana smoke.
Regardless of the THC content, the amount of tar inhaled by marijuana smokers and the level of carbon monoxide absorbed are three to five times greater than among tobacco smokers. This may be due to the marijuana users inhaling more deeply and holding the smoke in the lungs.
Recent findings indicate that smoking marijuana while shooting up cocaine has the potential to cause severe increases in heart rate and blood pressure. In one study, experienced marijuana and cocaine users were given marijuana alone, cocaine alone, and then a combination of both. Each drug alone produced cardiovascular effects; when they were combined, the effects were greater and lasted longer. The heart rate of the subjects in the study increased 29 beats per minute with marijuana alone and 32 beats per minute with cocaine alone. When the drugs were given together, the heart rate increased by 49 beats per minute, and the increased rate persisted for a longer time. The drugs were given with the subjects sitting quietly. In normal circumstances, an individual may smoke marijuana and inject cocaine and then do something physically stressful that may significantly increase risks of overload on the cardiovascular system.
A study of college students has shown that critical skills related to attention, memory, and learning are impaired among people who use marijuana heavily, even after discontinuing its use for at least 24 hours. Researchers compared 65 "heavy users," who had smoked marijuana a median of 29 of the past 30 days, and 64 "light users," who had smoked a median of 1 of the past 30 days. After a closely monitored 19- to 24-hour period of abstinence from marijuana and other illicit drugs and alcohol, the undergraduates were given several standard tests measuring aspects of attention, memory, and learning. Compared to the light users, heavy marijuana users made more errors and had more difficulty sustaining attention, shifting attention to meet the demands of changes in the environment, and in registering, processing, and using information. The findings suggest that the greater impairment among heavy users is likely due to an alteration of brain activity produced by marijuana.
Longitudinal research on marijuana use among young people below college age indicates those who used have lower achievement than the non-users, more acceptance of deviant behavior, more delinquent behavior and aggression, greater rebelliousness, poorer relationships with parents, and more associations with delinquent and drug-using friends.
Research also shows more anger and more regressive behavior (thumb sucking, temper tantrums) in toddlers whose parents use marijuana than among the toddlers of non-using parents.
Any drug of abuse can affect a mother's health during pregnancy, and this is a time when she should take special care of herself. Drugs of abuse may interfere with proper nutrition and rest, which can affect good functioning of the immune system. Some studies have found that babies born to mothers who used marijuana during pregnancy were smaller than those born to mothers who did not use the drug. In general, smaller babies are more likely to develop health problems.
A nursing mother who uses marijuana passes some of the THC to the baby in her breast milk. Research indicates that the use of marijuana by a mother during the first month of breast-feeding can impair the infant's motor development (control of muscle movement).
A drug is addicting if it causes compulsive, often uncontrollable drug craving, seeking, and use, even in the face of negative health and social consequences. Marijuana meets this criterion. More than 120,000 people seek treatment per year for their primary marijuana addiction. In addition, animal studies suggest marijuana causes physical dependence, and some people report withdrawal symptoms.
Monitoring the Future Study (MTF) *
The NIDA-funded MTF provides an annual assessment of drug use among 12th, 10th, and 8th grade students and young adults nationwide. After decreasing for over a decade, marijuana use among students began to increase in the early 1990s. From 1996 to 1997, use of marijuana at least once (lifetime use) increased among 12th and 10th graders, continuing the trend seen in recent years. The seniors' rate of lifetime marijuana use is higher than any year since 1987, but all rates remain well below those seen in the late 1970s and early 1980s. Past year and past month marijuana use did not change significantly from 1996 to 1997 in any of the three grades, suggesting the sharp increases of recent years may be slowing. Daily marijuana use in the past month increased among 12th graders, but decreased among 8th graders; this pattern of increases among older students and stable or declining rates among younger students was found with several indicators in the 1997 MTF.
Percentage of 8th-Graders Who Have Used Marijuana:
Monitoring the Future Study
Percentage of 10th-Graders Who Have Used Marijuana:
Monitoring the Future Study
Percentage of 12th-Graders Who Have Used Marijuana
Monitoring the Future Study
The resurgence in marijuana use continues, especially among adolescents, with rates of emergency department mentions of marijuana increasing from 1994 to 1995 in 10 cities, the percentage of treatment admissions increasing in 13 areas, and the National Institute of Justice's Drug Use Forecasting (DUF) percentages increasing among juvenile arrests at numerous sites. In several cities, such as Minneapolis/St. Paul, increasing treatment figures have been particularly notable among juveniles. Two factors may be contributing to the dramatic leap in adverse consequences: higher potency and the use of marijuana mixed with or in combination with other dangerous drugs.
Marijuana remains the most commonly used illicit drug in the United States. There were an estimated 2.4 million people who started using marijuana in 1995. According to data from the 1996 NHSDA, more than 68.6 million Americans (32 percent) 12 years of age and older have tried marijuana at least once in their lifetimes, and almost 18.4 million (8.6 percent) had used marijuana in the past year. In 1985, 56.5 million Americans (29.4 percent) had tried marijuana at least once in their lifetimes, and 26.1 million (13.6 percent) had used marijuana within the past year.
* MTF is an annual survey on drug use and related attitudes of America's adolescents that began in 1975. The survey is conducted by the University of Michigan's Institute for Social Research and is funded by NIDA. Copies of the latest survey are available from the National Clearinghouse for Alcohol and Drug Information at 1-800-729-6686.
** CEWG is a NIDA-sponsored network of researchers from 20 major U.S. metropolitan areas and selected foreign countries who meet semiannually to discuss the current epidemiology of drug abuse. CEWG's most recent report is Epidemiologic Trends in Drug Abuse, Volumes I and II, December 1996.
t NHSDA is an annual survey conducted by the Substance Abuse and Mental Health Services Administration.
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