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The trafficking and abuse of ketamine are a concern to law enforcement and drug treatment providers because of the drug's increasing availability and its use in facilitating sexual assaults. Ketamine is frequently smuggled into the country from Mexico and is commonly distributed by Caucasian males, although Mexican criminal groups increasingly distribute the drug.
Ketamine hydrochloride, a Schedule III drug under the Controlled Substances Act, is a dissociative anesthetic that has a combination of stimulant, depressant, hallucinogenic, and analgesic properties. Legally used as a preoperative veterinary anesthetic, ketamine is abused for these properties and used to facilitate sexual assault. Common street names for ketamine are K, special K, ket, kit kat, vitamin K, purple, special la coke, cat valium, super acid, super C, lady K, super K, ketaject, and cat tranquilizers.
Distribution of liquid and powdered ketamine typically occurs among friends and acquaintances, most often at raves, nightclubs, and at private parties; street sales of ketamine are rare. Caucasian males between the ages of 17 and 25 are the primary distributors of ketamine, but Mexican criminal groups are increasingly distributing the drug, particularly in the Rocky Mountain High Intensity Drug Trafficking Area (HIDTA). Retail quantities of powdered ketamine (100 mg to 200 mg) typically are packaged in small glass vials, small plastic bags, and capsules as well as paper, glassine, or aluminum foil folds. Law enforcement reporting indicates that liquid ketamine can be purchased for $20 to $140 per 10-milliliter vial, while powdered ketamine typically sells for $40 to $100 per gram.
Ketamine is produced commercially in a number of countries including Belgium, China, Colombia, Germany, Mexico, and the United States. Ketamine production is a complex and time-consuming process, making clandestine production impractical. For this reason most of the ketamine illegally distributed in the United States is diverted or stolen from legitimate sources, particularly veterinary clinics, or smuggled into the United States from Mexico.
Mexico is a significant source of ketamine available in the United States. The drug often is diverted from pharmaceutical manufacturers and veterinary clinics in Mexico and smuggled into the United States for distribution in markets throughout the country.
Ketamine is manufactured commercially as a powder or liquid. Users sometimes evaporate liquid ketamine on hot plates, on warming trays, or in microwave ovens, a process that results in the formation of crystals, which are then ground into powder. Powdered ketamine is cut into lines known as bumps and snorted, or it is smoked--typically in marijuana or tobacco cigarettes. Liquid ketamine is injected or ingested after being mixed into drinks.
Ketamine may be used in drug-facilitated sexual assaults because of its sedative and dissociative properties. When used in the commission of this crime, offenders often mix ketamine into victims' drinks--usually without their knowledge--or encourage victims to try it. Ketamine is included in the Drug-Induced Rape Prevention Act of 1996, and any offender convicted of using the drug to facilitate a rape or any other violent crime may face a prison term of up to 20 years.
Ketamine is rapidly metabolized by the body and therefore is difficult to detect through urine or blood toxicology testing beyond 48 hours after ingestion. Routine urine screening is often ineffective in detecting ketamine even within 48 hours; however, a number of advanced commercial toxicology tests will detect the drug and its metabolites.
The duration and severity of the effects of ketamine use are dose-dependent and affected by the method of administration as well as the user's weight and health (see Table?1). Common effects include amnesia, agitation, paralysis, memory loss, unconsciousness, nausea, and delirium. The onset of effects is rapid and often occurs within a few minutes of administration.
Out-of-body, near death hallucinations; terrors
Source Drug Identification Bible 2001.
Source Drug Identification Bible 2001.
Ketamine abuse may decrease in the near term. Monitoring the Future (MTF) data indicate that rates of past year use for ketamine have trended downward among adolescents and young adults, although none of the declines have been statistically significant. MTF data show that the percentage of eighth graders reporting past year ketamine use declined from 1.3 percent in 2002 to 1.1 percent in 2003. Past year rates of use among tenth graders declined from 2.2 percent in 2002 to 1.9 percent in 2003 and for twelfth graders from 2.6 percent to 2.1 percent. The percentage of college students (aged 19 to 22) reporting past year ketamine use declined from 1.3 percent in 2002 to 1.0 in 2003, while the percentage of young adults (aged 19 to 28) declined from 1.2 to 0.9. Furthermore, the consequences of ketamine abuse appear to be decreasing. Drug Abuse Warning Network (DAWN) data indicate that emergency department mentions for ketamine decreased sharply from 679 in 2001 to 260 in 2002.
U.S. Department of Health and Human Services
National Institutes of Health
National Institute on Drug Abuse
Monitoring the Future
Substance Abuse and Mental Health Services Administration
Office of Applied Studies
Drug Abuse Warning Network
U.S. Department of Justice
Drug Enforcement Administration
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